Labu Kuning / Pumpkin (Cucurbita moschata Durch)

Pumpkin  (Cucurbita moschata Durch)

1. Name of Plants
Plants Cucubita moschata Duch ex Poiret, has several local names, that areLabu parang ( Melayu), Waluh (Sunda), Waluh (Jawa Tengah).

 Foreign name: butternut (English)

 2. Classification of Plants
Division : Spermatophyta
Subdivision : Angiospermae
Class : Dicotyledonae
Order : Cucurbitales
Family : Cucurbitaceae
Genus : Cucubita
Species : Cucubita moschata Duch
(Hutapea, J.R, et al., 1994)

3. Description of Plants
Pumpkin plants derived from Ambon (Indonesia). There are five species commonly known pumpkin, that are Cucubita maxima Duchenes, Cucurbita ficifolia Bouche, Cucurbita mixta, Cucubita moschata Duchenes, and Cucurbita pipo L. These five Cucurbita species in Indonesia called pumpkin because it has similar characteristics.
Pumpkin fruit is round flat, oval, or long with lots of groove (groove 15-30). Size rapid growth, reaching 350 grams per day.

4. Chemical Ingredients and Benefits of Plants
Pumpkin contain the carotenoid (betakaroten), Vitamin A and C, mineral,
fats and carbohydrates.
Two phenolic glycosides compounds have been isolated from the seeds of Cucurbita moschata are (2-hydroxy)phenylcarbinyl 5-O-benzoyl-beta-D-apiofuranosyl(1–>2)-beta-D-glucopyranoside (1) dan 4-beta-D-(glucopyranosyl hydroxymethyl)phenyl 5-O-benzoyl-beta-D-apiofuranosyl(1–>2)-beta-D-glucopyranoside (2) (Li et al., 2009).

Five new phenolic glycoside compounds cucurbitosidesA—E (1—5), isolated from the seeds Cucurbita moschata are 2-(4-hydroxy)phenylethanol 4-O-(5-O-benzoyl)-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (1), 2-(4-hydroxyphenyl)ethanol 4-O-[5-O-(4-hydroxy)benzoyl]-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (2), 4-hydroxybenzyl alcohol 4-O-(5-O-benzoyl)-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (3), 4-hydroxybenzyl alcohol 4-O-[5-O-(4-hydroxy)benzoyl]-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (4) and 4-hydroxyphenyl 5-O-benzoyl-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (5) (Koike K., et al., 2005).

Phenolic glycosides compounds newly discovered is phenylcarbinyl 5-O-(4-hydroxy)benzoyl-beta-D-apiofuranosyl (1–>2)-beta-D-glucopyranoside selain 1-O-benzyl[5-O-benzoyl-beta-D-apiofuranosyl(1-->2)]-beta-D-glucopyranoside 2, cucurbitosides C 3 and A 4 (Li FS et al., 2009).

The leaves serve as a useful vegetable seeds and watermelon seeds to be used. Water fruit, useful as an antidote to the poison of venomous animals, while the seeds into a tapeworm medication. Flesh also contains anti-oxidants as cancer antidote. Pumpkin can also be used to cure inflammations, kidney treatment, fever, and diarrhea.

6. Mechanism of Anticancer Research

Has conducted research in silico enzyme acyl CoA diacylglycerol acyltransferase (DGAT, EC 2.3.120). Template use (PDB ID: 1K30).

Contributors : Sarmoko, Rina Maryani