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Saga/Red Lucky Seed (Abrus precatorius Linn)

Saga/Red Lucky Seed (Abrus precatorius Linn)

Figure 1. Red Lucky Seed Plant

 

1. Name of Plant

 

Local name: saga

 

Herb name: Abri Folium

 

2. Classification of Plant

 

Division : Spermatophyta
Sub division : Angiosperrnae
Class : Dicotyledonae
Order : Resales
Family : Leguminosae
Genus : Abrus
Species : Abrus precatorius Linn
(Inventaris Tanaman Obat Indonesia, 1994).

 

3. Morphology of Plant
Copound leaves, egg round shaped also small sized. Red Lucky Seed finned odd and has a bit sweet taste. Red Lucky Seed has pods contain red seeds with black shine spot and slippery. The flowers are purple with shape like butterflies, in the bunches of flower.

 

4. Chemical Ingredients
Leaves or root contain protein, vitamin A,B1, B6, C, calcium oxalate, glisirizin, flisirizinat, polygalacturomic acid and pentosan. Leaves, stalk, and seed : saponin and flavonoid. Stalk : polifenol. Seed : tannin. Root : alkaloid, saponin and polifenol.

 

Chemical compounds are luteolin, Isoorientin, L-Abrine, Precatorin I, II, III, Abruquinone D, E, F, Abrussaponin I, II (further more click here).

 

Benefit and Efficacy
Efficacious as thrush medication, cough medicine and sore throat medicine.

5. Habitat and Spread

Figure 2. Red Lucky Seed

 

This plants grow wild in the forest, fields or purposely planted in the yard. Grow well in the lowland until plateau 1000 meter above the sea level.

 

6. Anticancer Mechanism Research

 

Abrin and agglutinin-I from the seeds of Abrus precatorius are type II ribosome-inactivating proteins that inhibit protein synthesis in eukaryotic cells. The two toxins share a high degree of sequence similarity; however, agglutinin-I is weaker in its activity (Bagaria et al., 2006).

Abrus agglutinin (AAG), a hetero tetrameric gal beta (1-3) NAc gal specific lectin, is isolated from seeds of Abrus precatorius. In our previous studies we found that the protein could act as an immunomodulator and immunoadjuvant in native (NA) and heat denatured (HDA) conditions. An anticancer effect of the lectin is reported, but its mode of action is not clearly known (Gosh, 2007).


References:

Inventaris Tanaman Obat Indonesia, 1994

Ashima Bagaria, A., Surendranath, K., Ramagopal, U.A., Ramakumar, S., Karande, A.A., 2006, Structure-Function Analysis and Insights into the Reduced Toxicity of Abrus precatorius Agglutinin I in Relation to Abrin, The Journal of Biological Chemistry,   281,  34465-74.

Ghosh D, Maiti TK., 2007, Immunomodulatory and anti-tumor activities of native and heat denatured Abrus agglutinin, Immunobiology, 212(7):589-99

Contributor: Sarmoko

Gambar 2. Buah saga

Tumbuhan ini banyak tumbuh secara liar di hutan-hutan, ladang-ladang atau sengaja dipelihara di pekarangan. Tumbuh dengan baik pada daerah dataran rendah sampai ketinggian 1000 meter di atas permukaan laut.

6. Penelitian mekanisme antikanker

Abrin and agglutinin-I from the seeds of Abrus precatorius are type II ribosome-inactivating proteins that inhibit protein synthesis in eukaryotic cells. The two toxins share a high degree of sequence similarity; however, agglutinin-I is weaker in its activity (Bagaria et al., 2006).

Abrus agglutinin (AAG), a hetero tetrameric gal beta (1-3) NAc gal specific lectin, is isolated from seeds of Abrus precatorius. In our previous studies we found that the protein could act as an immunomodulator and immunoadjuvant in native (NA) and heat denatured (HDA) conditions. An anticancer effect of the lectin is reported, but its mode of action is not clearly known (Gosh, 2007).

Daftar Pustaka

Inventaris Tanaman Obat Indonesia, 1994

Ashima Bagaria, A., Surendranath, K., Ramagopal, U.A., Ramakumar, S., Karande, A.A., 2006, Structure-Function Analysis and Insights into the Reduced Toxicity of Abrus precatorius Agglutinin I in Relation to Abrin, The Journal of Biological Chemistry,   281,  34465-74.

Ghosh D, Maiti TK., 2007, Immunomodulatory and anti-tumor activities of native and heat denatured Abrus agglutinin, Immunobiology, 212(7):589-99

Kontributor: Sarmoko